Healthy Living 15 Early Warning Signs of Lupus Prev Slide 2 / 9 Next Prev Next 9. Hair loss To view this video please enable JavaScript, and consider upgrading to a web browser that supports HTML5 video Inflammation of the skin and scalp causes thinning hair and hair loss. Hair thins out slowly, and you may not notice it for a time. Lupus causes hair to break easily, feel brittle, and look ragged.