What medicine can I take to prevent ear pain during a flight?

I have a cold and I am worried I will end up with ear pain during my long plane flight. What medicine can I take to prevent ear pain while flying?

Ear plugs, nasal decongestants, or oral decongestants.

Set up from eardrum perforation, ear pain. Could use oxymetozoline nasal spray. No alcohol on flight. Turn off the air blower.