
Dr. John Frederick Payne M.D.
OB-GYN (Obstetrician-Gynecologist) | Reproductive Endocrinology
5500 Front St 410 Summerville South Carolina, 29486About
Dr. Payne is a native South Carolinian. He finished his undergraduate degree at Furman University and earned his Medical Degree from the Medical University of South Carolina in Charleston. He specialized in Obstetrics and Gynecology, completing his Internship and Residency at Madigan Army Medical Center and then subspecialized in Reproductive Endocrinology and Infertility completing his REI Fellowship at Duke University Medical Center.
Dr. Payne served in our U.S. Army for 17 years and had a distinguished military career achieving the rank of Lieutenant Colonel. He was awarded many honors including the Army Meritorious Service Medal in Operation Iraqi Freedom, the Iraqi Campaign Medal, Overseas Service Ribbon, and Global War on Terrorism Service Medal.
He was the Division Director for REI at Walter Reed Army Medical Center in Washington, DC overseeing the military’s largest IVF practice with over 450 cycles yearly and has trained many OBGYN residents and REI fellows and held multiple academic appointments including Assistant Professor, OB/GYN at USUHS School of Medicine, Clinical Associate, OB/GYN at Duke University Medical Center, and Clinical Instructor, OB/GYN at the Medical College of Georgia.
Dr. Payne has been published and presented numerous times. He is double Board Certified in OB/GYN as well as Reproductive Endocrinology and Infertility. In 2007, Dr. Payne joined Piedmont Reproductive Endocrinology Group (PREG), later became a partner at PREG and serves as the director of third party reproduction. He is married with three children.
Education and Training
Medical University of South Carolina College of Medicine 1992
Board Certification
American Board of Obstetrics and Gynecology
Reproductive Endocrinology/Infertility (Obstetrics and Gynecology)
Provider Details

Dr. John Frederick Payne M.D.'s Expert Contributions
I'm pregnant and feel like I have period cramps?
It can be normal due to round ligament pain but I suggest you see your obstetrician to be evaluated. READ MORE
Could I be pregnant?
Please see your family physician. READ MORE
Am I ready to push my water broke?
Go to the hospital immediately! READ MORE
Areas of expertise and specialization
Treatments
- Infertility
- Endometriosis
- Pregnancy
- Birth Defects
- Hypothyroidism
Dr. John Frederick Payne M.D.'s Practice location
Dr. John Payne, MD
17 Caledon Court Suite C -Greenville, SC 29615Get Direction
Piedmont Reproductive Endocrinology Group
1330 Boiling Springs Rd 2200 -Spartanburg, South Carolina 29303Get Direction
Piedmont Reproductive Endocrinology Group
76 Peachtree Rd 210 -Asheville, North Carolina 28803Get Direction
Piedmont Reproductive Endocrinology Group
2324 Sunset Blvd -West Columbia, South Carolina 29169Get Direction
Piedmont Reproductive Endocrinology Group
5500 Front St 410 -Summerville, South Carolina 29486Get Direction
Dr. John Frederick Payne M.D.'s reviews
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Get to know Reproductive Endocrinologist Dr. John F. Payne, who serves patients throughout the State of South Carolina and western North Carolina.
Dr. Payne is a board-certified reproductive endocrinologist whose areas of expertise include infertility and in-vitro fertilization, reproductive endocrine disorders and menopause, polycystic ovary syndrome, endometriosis, pubertal abnormalities, and advanced surgical procedures. He is a Partner and the Director of Third Party Reproduction at Piedmont Reproductive Endocrinology Group with offices throughout the State of South Carolina, including Greenville, Columbia, Asheville, and Spartanburg.
Piedmont Reproductive Endocrinology Group is one of the nation’s leading fertility clinics. IUI, IVF, egg donors, surrogacy, and embryo adoption are just a few of the many options they have available to help those who wish to start a family. The Group has received local and national attention for being leaders in the field of reproductive medicine. Their commitment to IVF success has made them a patient’s first choice in fertility care.
A native South Carolinian, Dr. Payne finished his undergraduate degree at Furman University and earned his medical degree from the Medical University of South Carolina in Charleston. He specialized in obstetrics and gynecology, completing his internship and residency at Madigan Army Medical Center. He then subspecialized in reproductive endocrinology and infertility, completing his REI Fellowship at Duke University Medical Center.
The doctor served in the U.S. Army for 17 years and had a distinguished military career, achieving the rank of Lieutenant Colonel. He was awarded many honors, including the Army Meritorious Service Medal in Operation Iraqi Freedom, the Iraqi Campaign Medal, the Overseas Service Ribbon, and the Global War on Terrorism Service Medal.
He was the Division Director for REI at Walter Reed Army Medical Center in Washington, D.C., where he oversaw the military’s largest IVF practice with over 450 cycles yearly, trained many OB/GYN residents and REI fellows, as well as held multiple academic appointments, including Assistant Professor of Obstetrics and Gynecology at USUHS School of Medicine, Clinical Associate of Obstetrics and Gynecology at Duke University Medical Center, and Clinical Instructor of Obstetrics and Gynecology at the Medical College of Georgia.
In addition to having been published and having presented numerous times, Dr. Payne is double board-certified in obstetrics and gynecology & reproductive endocrinology and infertility by the American Board of Obstetrics and Gynecology (ABOG). The ABOG is a non-profit organization that provides board certification for practicing obstetricians and gynecologists in the United States and Canada.
Reproductive endocrinology and infertility (REI) is a surgical subspecialty of obstetrics and gynecology that trains physicians in reproductive medicine addressing hormonal functioning as it pertains to reproduction, as well as the issue of infertility. Reproductive endocrinologists are the only doctors trained in providing fertility treatments using assisted reproductive technologies (ART) such as in vitro fertilization (IVF) and egg freezing. They are also trained in obstetrics and gynecology, and then have additional training to provide fertility treatment.
Happily married, Dr. Payne and his wife have three children.
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