Dr. Mark Anthony Perrella MD
Pulmonologist | Pulmonary Disease
75 Francis St Brigham And Womens H Boston MA, 02115About
Dr. Mark Perrella practices Pulmonology in Boston, MA. A pulmonologist is a physician who possesses specialized knowledge and skill in the diagnosis and treatment of pulmonary conditions and diseases. Dr. Perrella manages patients who need life support and mechanical ventilation, and is specially trained in diseases and conditions of the chest, particularly pneumonia, asthma, tuberculosis, emphysema, and complicated chest infections.
Education and Training
Rutgers 1986
Board Certification
Internal MedicineAmerican Board of Internal MedicineABIM
Provider Details
Expert Publications
Data provided by the National Library of Medicine- Interferon-gamma-mediated inhibition of cyclin A gene transcription is independent of individual cis-acting elements in the cyclin A promoter.
- Genomic cloning and promoter analysis of aortic preferentially expressed gene-1. Identification of a vascular smooth muscle-specific promoter mediated by an E box motif.
- Generation of a dominant-negative mutant of endothelial PAS domain protein 1 by deletion of a potent C-terminal transactivation domain.
- Induction of high mobility group I architectural transcription factors in proliferating vascular smooth muscle in vivo and in vitro.
- Role of activating protein-1 and high mobility group-I(Y) protein in the induction of CD44 gene expression by interleukin-1beta in vascular smooth muscle cells.
- Thioredoxin facilitates the induction of heme oxygenase-1 in response to inflammatory mediators.
- Transforming growth factor-beta 1 inhibits cytokine-mediated induction of human metalloelastase in macrophages.
- Prevention of hypoxia-induced pulmonary hypertension by enhancement of endogenous heme oxygenase-1 in the rat.
- Transforming growth factor-beta 1 inhibition of macrophage activation is mediated via Smad3.
- Striated muscle preferentially expressed genes alpha and beta are two serine/threonine protein kinases derived from the same gene as the aortic preferentially expressed gene-1.
- Inhibition of E-selectin gene expression by transforming growth factor beta in endothelial cells involves coactivator integration of Smad and nuclear factor kappaB-mediated signals.
- CLIF, a novel cycle-like factor, regulates the circadian oscillation of plasminogen activator inhibitor-1 gene expression.
- ESE-1 is a novel transcriptional mediator of inflammation that interacts with NF-kappa B to regulate the inducible nitric-oxide synthase gene.
- Down-regulation of high mobility group-I(Y) protein contributes to the inhibition of nitric-oxide synthase 2 by transforming growth factor-beta1.
- Endotoxin-induced mortality is related to increased oxidative stress and end-organ dysfunction, not refractory hypotension, in heme oxygenase-1-deficient mice.
Dr. Mark Anthony Perrella MD's Practice location
Practice At 75 Francis St Brigham And Womens Hospital
75 Francis St Brigham And Womens H -Boston, MA 02115Get Direction
Mark Perrella, MD
Pulmonary & Critical Care Division Thorn 931a Brigham And Womens H -Boston, MA 02115Get Direction
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