Dr. Reuben Paul Siraganian M.D.
Allergist and Immunologist | Allergy
National Institutes Of Health Building 49, 1a16 Bethesda MD, 20892About
Dr. Reuben Siraganian practices Allergy and Immunology care in Bethesda, MD. Dr. Siraganian specializes in the diagnosis and treatment of asthma and other allergic diseases. Allergist-Immunologists are trained and certified to treat each patients sensitivity and response to allergens of varying severity. Dr. Siraganian provides several means of testing and treatment to increase immunity to potentially harmful substances.
Education and Training
Suny-Hlth Sci Ctr At Brooklyn, Coll of Med, Brooklyn Ny 1962
Board Certification
Allergy and ImmunologyAmerican Board of Allergy and ImmunologyABAI
Provider Details
Expert Publications
Data provided by the National Library of Medicine- Evidence that the "mouse mastocytoma" cell line (MCT-1) is of rat origin.
- Evidence that the "mouse mastocytoma" cell line (MCT-1) is of rat origin.
- CD45 is essential for Fc epsilon RI signaling by ZAP70, but not Syk, in Syk-negative mast cells.
- Point mutation of a tyrosine in the linker region of Syk results in a gain of function.
- The Src homology 2 domain of Vav is required for its compartmentation to the plasma membrane and activation of c-Jun NH(2)-terminal kinase 1.
- Positive regulation of c-Jun N-terminal kinase and TNF-alpha production but not histamine release by SHP-1 in RBL-2H3 mast cells.
- Regulation of protein kinase CbetaI by two protein-tyrosine kinases, Btk and Syk.
- The NH2-terminal region of focal adhesion kinase reconstitutes high affinity IgE receptor-induced secretion in mast cells.
- Phosphorylation of Syk activation loop tyrosines is essential for Syk function. An in vivo study using a specific anti-Syk activation loop phosphotyrosine antibody.
- Mutant RBL mast cells defective in Fc epsilon RI signaling and lipid raft biosynthesis are reconstituted by activated Rho-family GTPases.
- Identification and isolation of rat bone marrow-derived mast cells using the mast cell-specific monoclonal antibody AA4.
- Activated Cdc42/Rac reconstitutes Fcepsilon RI-mediated Ca2+ mobilization and degranulation in mutant RBL mast cells.
- SH2 domain-mediated targeting, but not localization, of Syk in the plasma membrane is critical for FcepsilonRI signaling.
- Refinements in the automated fluorometric histamine analysis system.
- Monomeric IgE stimulates signaling pathways in mast cells that lead to cytokine production and cell survival.
Dr. Reuben Paul Siraganian M.D.'s Practice location
Reuben Siraganian
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