Dr. Gilbert Chu MD

Treatments

• Pancreatic Cancer
• Colon Cancer

Fellowships

• Stanford University School of Medicine,Stanford, Ca, United States   1986

Publications

• JOURL OF BIOLOGICAL CHEMISTRYCooperative Assembly of a Protein-D Filament for Nonhomologous End Joining2013
• CELLHere Comes the Sun: Recognition of UV-Damaged D2008
• PROCEEDINGS OF THE TIOL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMCernunnos/XLF promotes the ligation of mismatched and noncohesive D ends2007
• JOURL OF BIOLOGICAL CHEMISTRYProcessing of D for nonhomologous end-joining is controlled by kise activity and XRCC4/Ligase IV2007
• EMBO JOURLProcessing of D for nonhomologous end-joining by cell-free extract2005
• PROCEEDINGS OF THE TIOL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMToxicity from radiation therapy associated with abnormal transcriptiol responses to D damage2004
• PROCEEDINGS OF THE TIOL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMSignificance alysis of microarrays applied to the ionizing radiation response2001
• Methods in molecular biology (Clifton, N.J.)Electrophoretic mobility shift assays for protein-D complexes involved in D repair.2012
• PLOS ONEAn Information Theoretic2011
• MOLECULAR CELLCrystal structure of human XLF: A twist in nonhomologous D end-joining2007
• Methods in molecular biology (Clifton, N.J.)Electrophoretic mobility shift assays to study protein binding to damaged D.2006
• D REPAIR, PT AAssays for nonhomologous end joining in extracts2006
• Rieger, K. E., Hong, W. J., Tusher, V. G., Tang, J., Tibshirani, R., CToxicity from radiation therapy associated with abnormal transcriptiol responses to D damage2004
• NUCLEIC ACIDS RESEARCHPortrait of transcriptiol responses to ultraviolet and ionizing radiation in human cells2004
• STATISTICAL SCIENCEClass prediction by nearest shrunken centroids, with applications to D microarrays2003
• JOURL OF BIOLOGICAL CHEMISTRYInteraction between UV-damaged D binding activity proteins and the c-Abl tyrosine kise2002
• D REPAIRXeroderma pigmentosum complementation group E and UV-damaged D-binding protein2002
• EMBO JOURLSypsis of D ends by D-dependent protein kise2002
• PROCEEDINGS OF THE TIOL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMDiagnosis of multiple cancer types by shrunken centroids of gene expression2002
• COMPSTAT 2002: PROCEEDINGS IN COMPUTATIOL STATISTICSSupervised learning from microarray data2002
• JOURL OF BIOLOGICAL CHEMISTRYActivation of D-dependent protein kise by single-stranded D ends2000
• EMBO JOURLStructure of D-dependent protein kise: implications for its regulation by D1999
• PROCEEDINGS OF THE TIOL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMExpression of the p48 xeroderma pigmentosum gene is p53-dependent1999
• Methods in molecular biology (Clifton, N.J.)The use of electrophoretic mobility shift assays to study D repair.1999
• MOLECULAR AND CELLULAR BIOLOGYFailure of hairpin-ended and nicked D to activate D-dependent protein kise1998
• MOLECULAR AND CELLULAR BIOLOGYp48 activates a UV-damaged-D binding factor1998
• PROCEEDINGS OF THE TIOL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMD-dependent protein kise: D binding and activation in the absence of Ku1998
• JOURL OF BIOLOGICAL CHEMISTRYDouble strand break repair1997
• Semirs in immunologyThe end-joining reaction in V(D)J recombition.1997
• CANCER RESEARCHD-dependent protein kise is not required for accumulation of p53 or cell cycle arrest after D1997
• MOLECULAR AND CELLULAR BIOLOGYKu86 defines the genetic defect and restores X-ray resistance and V1996
• MUTATION RESEARCH-D REPAIRIsolation of a cD encoding a UV1996
• MOLECULAR ALYSIS OF D REARRANGEMENTS IN THE IMMUNE SYSTEMRole of the Ku autoantigen in V(D)J recombition and double-strand break repair1996
• MOLECULAR AND CELLULAR BIOLOGYA NOVEL ROLE FOR D PHOTOLYASE1994
• SCIENCERESTORATION OF X-RAY RESISTANCE AND V(D)J RECOMBITION IN MUTANT-CELLS BY KU CD1994
• MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESISXERODERMA-PIGMENTOSUM GROUP-E BINDING-FACTOR RECOGNIZES A BROAD-SPECTRUM OF D-DAMAGE1994
• PROCEEDINGS OF THE TIOL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMINVOLVEMENT OF THE KU AUTOANTIGEN IN THE CELLULAR-RESPONSE TO D DOUBLE-STRAND BREAKS1994
• MOLECULAR AND CELLULAR BIOLOGYA D END-BINDING FACTOR INVOLVED IN DOUBLE-STRAND BREAK REPAIR AND V(D)J RECOMBITION1994
• JOURL OF BIOLOGICAL CHEMISTRYCELLULAR-RESPONSES TO CISPLATIN - THE ROLES OF D-BINDING PROTEINS AND D-REPAIR1994
• CANCERMASSIVE CISPLATIN OVERDOSE BY ACCIDENTAL SUBSTITUTION FOR CARBOPLATIN - TOXICITY AND MAGEMENT1993
• BIOCHEMISTRYPURIFICATION AND CHARACTERIZATION OF A HUMAN PROTEIN THAT BINDS TO DAMAGED D1993
• PROCEEDINGS OF THE TIOL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMBAG MODEL FOR D MIGRATION DURING PULSED-FIELD ELECTROPHORESIS1991
• MOLECULAR AND CELLULAR BIOLOGYPULSED-FIELD ELECTROPHORESIS OF MEGABASE-SIZED D1991
• ALYTICAL BIOCHEMISTRYSEPARATION OF LARGE D BY A VARIABLE-ANGLE CONTOUR-CLAMPED HOMOGENEOUS ELECTRIC-FIELD APPARATUS1991
• PROCEEDINGS OF THE TIOL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMCISPLATIN-RESISTANT CELLS EXPRESS INCREASED LEVELS OF A FACTOR THAT RECOGNIZES DAMAGED D1990
• SCIENCEXERODERMA PIGMENTOSUM GROUP-E CELLS LACK A NUCLEAR FACTOR THAT BINDS TO DAMAGED D1988
• JOURNAL OF BIOLOGICAL CHEMISTRYCooperative Assembly of a Protein-DNA Filament for Nonhomologous End Joining2013
• NUCLEIC ACIDS RESEARCHLocal false discovery rate facilitates comparison of different microarray experiments2009
• CELLHere Comes the Sun: Recognition of UV-Damaged DNA2008
• PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OCernunnos/XLF promotes the ligation of mismatched and noncohesive DNA ends2007
• JOURNAL OF BIOLOGICAL CHEMISTRYProcessing of DNA for nonhomologous end-joining is controlled by kinase activity and XRCC42007
• EMBO JOURNALProcessing of DNA for nonhomologous end-joining by cell-free extract2005
• PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OToxicity from radiation therapy associated with abnormal transcriptional responses to DNA damage2004
• PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OSignificance analysis of microarrays applied to the ionizing radiation response2001
• Methods in molecular biology (Clifton, N.J.)Electrophoretic mobility shift assays for protein-DNA complexes involved in DNA repair.2012
• PLOS ONEAn Information Theoretic2011
• MOLECULAR CELLCrystal structure of human XLF: A twist in nonhomologous DNA end-joining2007
• Methods in molecular biology (Clifton, N.J.)Electrophoretic mobility shift assays to study protein binding to damaged DNA.2006
• DNA REPAIR, PT AAssays for nonhomologous end joining in extracts2006
• Rieger, K. E., Hong, W. J., Tusher, V. G., Tang, J., Tibshirani, R., CToxicity from radiation therapy associated with abnormal transcriptional responses to DNA damage2004
• NUCLEIC ACIDS RESEARCHPortrait of transcriptional responses to ultraviolet and ionizing radiation in human cells2004
• STATISTICAL SCIENCEClass prediction by nearest shrunken centroids, with applications to DNA microarrays2003
• JOURNAL OF BIOLOGICAL CHEMISTRYInteraction between UV-damaged DNA binding activity proteins and the c-Abl tyrosine kinase2002
• DNA REPAIRXeroderma pigmentosum complementation group E and UV-damaged DNA-binding protein2002
• EMBO JOURNALSynapsis of DNA ends by DNA-dependent protein kinase2002
• PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES ODiagnosis of multiple cancer types by shrunken centroids of gene expression2002
• MOLECULAR AND CELLULAR BIOLOGYp53 binds and activates the xeroderma pigmentosum DDB2 gene in humans but not mice2002
• COMPSTAT 2002: PROCEEDINGS IN COMPUTATIONAL STATISTICSSupervised learning from microarray data2002
• MOLECULAR CELLXeroderma pigmentosum p48 gene enhances global genomic repair and suppresses UV-induced mutagenesis2000
• JOURNAL OF BIOLOGICAL CHEMISTRYActivation of DNA-dependent protein kinase by single-stranded DNA ends2000
• EMBO JOURNALStructure of DNA-dependent protein kinase: implications for its regulation by DNA1999
• PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OExpression of the p48 xeroderma pigmentosum gene is p53-dependent1999
• Methods in molecular biology (Clifton, N.J.)The use of electrophoretic mobility shift assays to study DNA repair.1999
• MOLECULAR AND CELLULAR BIOLOGYFailure of hairpin-ended and nicked DNA to activate DNA-dependent protein kinase1998
• MOLECULAR AND CELLULAR BIOLOGYp48 activates a UV-damaged-DNA binding factor1998
• PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES ODNA-dependent protein kinase: DNA binding and activation in the absence of Ku1998
• JOURNAL OF BIOLOGICAL CHEMISTRYDouble strand break repair1997
• Seminars in immunologyThe end-joining reaction in V(D)J recombination.1997
• CANCER RESEARCHDNA-dependent protein kinase is not required for accumulation of p53 or cell cycle arrest after DNA1997
• TRENDS IN GENETICSXeroderma pigmentosum, Cockayne syndrome and trichothiodystrophy1996
• MOLECULAR AND CELLULAR BIOLOGYKu86 defines the genetic defect and restores X-ray resistance and V1996
• MUTATION RESEARCH-DNA REPAIRIsolation of a cDNA encoding a UV1996
• MOLECULAR ANALYSIS OF DNA REARRANGEMENTS IN THE IMMUNE SYSTEMRole of the Ku autoantigen in V(D)J recombination and double-strand break repair1996
• MOLECULAR AND CELLULAR BIOLOGYA NOVEL ROLE FOR DNA PHOTOLYASE1994
• SCIENCERESTORATION OF X-RAY RESISTANCE AND V(D)J RECOMBINATION IN MUTANT-CELLS BY KU CDNA1994
• MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESISXERODERMA-PIGMENTOSUM GROUP-E BINDING-FACTOR RECOGNIZES A BROAD-SPECTRUM OF DNA-DAMAGE1994
• PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OINVOLVEMENT OF THE KU AUTOANTIGEN IN THE CELLULAR-RESPONSE TO DNA DOUBLE-STRAND BREAKS1994
• MOLECULAR AND CELLULAR BIOLOGYA DNA END-BINDING FACTOR INVOLVED IN DOUBLE-STRAND BREAK REPAIR AND V(D)J RECOMBINATION1994
• JOURNAL OF BIOLOGICAL CHEMISTRYCELLULAR-RESPONSES TO CISPLATIN - THE ROLES OF DNA-BINDING PROTEINS AND DNA-REPAIR1994
• CANCERMASSIVE CISPLATIN OVERDOSE BY ACCIDENTAL SUBSTITUTION FOR CARBOPLATIN - TOXICITY AND MANAGEMENT1993
• BIOCHEMISTRYPURIFICATION AND CHARACTERIZATION OF A HUMAN PROTEIN THAT BINDS TO DAMAGED DNA1993
• PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OBAG MODEL FOR DNA MIGRATION DURING PULSED-FIELD ELECTROPHORESIS1991
• MOLECULAR AND CELLULAR BIOLOGYPULSED-FIELD ELECTROPHORESIS OF MEGABASE-SIZED DNA1991
• ANALYTICAL BIOCHEMISTRYSEPARATION OF LARGE DNA BY A VARIABLE-ANGLE CONTOUR-CLAMPED HOMOGENEOUS ELECTRIC-FIELD APPARATUS1991
• PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OCISPLATIN-RESISTANT CELLS EXPRESS INCREASED LEVELS OF A FACTOR THAT RECOGNIZES DAMAGED DNA1990
• SCIENCEXERODERMA PIGMENTOSUM GROUP-E CELLS LACK A NUCLEAR FACTOR THAT BINDS TO DAMAGED DNA1988

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