Dr. David N. Palmer, MD

Expert Publications

• Enhanced expression of manganese-dependent superoxide dismutase in human and sheep CLN6 tissues.
• The analytical approach to the nature of lipofuscin (age pigment).
• The origin of fluorescence in the neuronal ceroid lipofuscinoses (Batten disease) and neuron cultures from affected sheep for studies of neurodegeneration.
• Defective endoplasmic reticulum-resident membrane protein CLN6 affects lysosomal degradation of endocytosed arylsulfatase A.
• Lysine 43 is trimethylated in subunit C from bovine mitochondrial ATP synthase and in storage bodies associated with batten disease.
• Glial activation spreads from specific cerebral foci and precedes neurodegeneration in presymptomatic ovine neuronal ceroid lipofuscinosis (CLN6).
• The development and characterisation of complex ovine neuron cultures from fresh and frozen foetal neurons.
• Activation of non-neuronal cells within the prenatal developing brain of sheep with neuronal ceroid lipofuscinosis.
• Neuronal ceroid lipofuscinosis in Devon cattle is caused by a single base duplication (c.662dupG) in the bovine CLN5 gene.
• A missense mutation (c.184C>T) in ovine CLN6 causes neuronal ceroid lipofuscinosis in Merino sheep whereas affected South Hampshire sheep have reduced levels of CLN6 mRNA.
• Metabolomic investigation of CLN6 neuronal ceroid lipofuscinosis in affected South Hampshire sheep.
• A new large animal model of CLN5 neuronal ceroid lipofuscinosis in Borderdale sheep is caused by a nucleotide substitution at a consensus splice site (c.571+1G>A) leading to excision of exon 3.
• Location and connectivity determine GABAergic interneuron survival in the brains of South Hampshire sheep with CLN6 neuronal ceroid lipofuscinosis.
• Neuropeptide changes and neuroactive amino acids in CSF from humans and sheep with neuronal ceroid lipofuscinoses (NCLs, Batten disease).
• The specific loss of GnRH-positive neurons from the hypothalamus of sheep with CLN6 neuronal ceroid lipofuscinosis occurs without glial activation and has only minor effects on reproduction.

Media Releases

Get to know Orthopedic Surgeon Dr. David N. Palmer, who serves patients in Savannah, Georgia.

With a distinguished pedigree as a board-certified, fellowship-trained orthopedic surgeon, Dr. Palmer’s expertise shines brightly in the specialized treatment of musculoskeletal injuries, particularly those afflicting the shoulder and knee. He is currently affiliated with Optim Orthopedics, tending to patients in Savannah, Georgia.

Back in the early days of his academic career, he graduated with his medical degree from the University of Florida in 1992, before completing his residency in orthopedic surgery at the University of Missouri at Kansas in 1997. Finally, he completed his fellowship in sports medicine at the Medical College of Virginia in 1998.

Subsequent to his education, the doctor attained board certification through the American Board of Orthopedic Surgery (ABOS). The ABOS is an organization with the goal of establishing educational and professional standards for orthopedic residents and surgeons as well as evaluating the qualifications and competence of orthopedic surgeons.

The roots of Dr. Palmer’s affinity for sports medicine run deep, intertwined with his personal and familial history. Notably, his brother Dean carved a notable path in Major League Baseball, playing for esteemed teams such as the Rangers, Royals, and Tigers. Yet, it was his journey that led him to Florida State University, where he not only pursued his athletic ambitions but also distinguished himself academically, earning the coveted status of Academic All-American.

His multifaceted role on the football field, encompassing positions as inside linebacker, running back, and fullback, underscored his versatility and determination. However, it was his exposure to the world of sports medicine, garnered through interactions with team physicians during his tenure at FSU, that ignited his passion for healing.

Within the realm of sports medicine, Dr. Palmer is renowned for his surgical prowess, having performed a myriad of arthroscopic procedures and knee replacements with remarkable success rates. His commitment to innovation is palpable, as he remains at the forefront of emerging technologies and methodologies in orthopedic surgery. Embracing groundbreaking advancements such as NeoCart, GelrinC, and the REGENETEN Bioinductive Implant, he epitomizes the spirit of pioneering exploration within his field. His eagerness to engage with novel products and technologies underscores his dedication to providing his patients with access to the most cutting-edge treatments available.

Orthopedic surgery is the branch of surgery concerned with conditions involving the musculoskeletal system. Orthopedic surgeons use both surgical and non-surgical means to treat musculoskeletal trauma, spine diseases, sports injuries, degenerative diseases, infections, tumors, and congenital disorders.

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