Dr. Brian Jay Druker MD
Hematologist-Oncologist | Hematology & Oncology
3181 Sw Sam Jackson Park Rd, L952 Mail Code L586 Portland OR, 97239About
Dr. Druker specializes in caring for and treating patients with chronic myelogenous leukemia (CML). In his early medical training, witnessing chemotherapy's effects on patients drove him to find a bet ...
Education and Training
Univ of Ca, San Diego, Sch of Med, La Jolla Ca 1981
Board Certification
Internal MedicineAmerican Board of Internal MedicineABIM- Medical Oncology
Internal MedicineAmerican Board of Internal MedicineABIM- 1984
Provider Details
Expert Publications
Data provided by the National Library of Medicine- CRKL binding to BCR-ABL and BCR-ABL transformation.
- CrkL and CrkII participate in the generation of the growth inhibitory effects of interferons on primary hematopoietic progenitors.
- Thrombopoietin-induced signal transduction and potentiation of platelet activation.
- Lessons learned from the development of an abl tyrosine kinase inhibitor for chronic myelogenous leukemia.
- IFN-gamma activates the C3G/Rap1 signaling pathway.
- Abl kinase but not PI3-kinase links to the cytoskeletal defects in Bcr-Abl transformed cells.
- Rapid tyrosine phosphorylation and activation of Bruton's tyrosine/Tec kinases in platelets induced by collagen binding or CD32 cross-linking.
- CrkL functions as a nuclear adaptor and transcriptional activator in
- The linker phosphorylation site Tyr292 mediates the negative regulatory effect of Cbl on ZAP-70 in T cells.
- All-trans-retinoic acid induces tyrosine phosphorylation of the CrkL adapter in acute promyelocytic leukemia cells.
- Inhibition of c-kit receptor tyrosine kinase activity by STI 571, a selective tyrosine kinase inhibitor.
- Abl protein-tyrosine kinase inhibitor STI571 inhibits in vitro signal transduction mediated by c-kit and platelet-derived growth factor receptors.
- Efficacy of STI571, an abl tyrosine kinase inhibitor, in conjunction with other antileukemic agents against bcr-abl-positive cells.
- Status of bcr-abl tyrosine kinase inhibitors in chronic myelogenous leukemia.
- Chronic myelogenous leukemia.
Fellowships
- DANA FARBER CANCER INST, BOSTON, MA,, Oncology 1987
- Medical Oncology - Dana-Farber Cancer Institute, Harvard Medical School, Boston
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Brian Druker, MD
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