Kathleen England, MS, PhD

Areas of expertise and specialization

Professional Memberships

• American Society of Microbiology  
• International Union for TB and Lung Infections  
• WHO Global Laboratory Initiative  
• African Society of Laboratory Medicine  

Internships

• World Health Organization (2009)

Fellowships

• National Institutes of Health, NIAID (2009-2011)

Articles and Publications

• COLLABORATIONS Innovations Document 2016-2020, KNCV TB foundation (2016), and internal strategy document with several lead KNCV collaborating authors, The Hague, NL Guide for providing technical support to TB laboratories in low- and middle-income countries, WHO Global Laboratory Initiatives, Dec. 2015, WHO Geneva, collaborating author (http://www.stoptb.org/wg/gli/assets/documents/guideforprovidingtechnicalsupport_gb_web.pdf) Building Bridges with North Korea: Engaging Through Health Diplomacy, (Spring 2014) K. England and E. Desmond, ASM Cultures Magazine, 1:2:26-33. https://www.amazon.com/Cultures-Publication-American-Microbiology-Diplomacy/dp/B07P9V1VT4 Featured in Chosen Daily Newspaper, Provision of medicine for tuberculosis? Right now, were lacking the medical personnel to diagnose the North Korean DRTB patients, (6/3/2013). http://news.chosun.com/site/data/html_dir/2013/06/03/2013060300153.html Featured in SCIENCE article by Richard Stone, Public Enemy Number One (2013) SCIENCE, Vol 340, p. 422-425. https://www.science.org/doi/10.1126/science.340.6131.422 North Korean Physicians and American Healthcare Workers Team-up to Fight TB Epidemic (2013) Gary K. Schoolnik, Heidi S. Linton and Kathleen D. England, Wall Street Journal (unpublished) Global Green Light Committee Mission Report, PMDT Monitoring Report - Democratic Peoples Republic of Korea (2012) F.Wares and K. England, World Health Organization. PROFESSIONAL Operationalizing Target-based Next-generation Sequencing for Routine Diagnosis of DRTB. Aparna Iyer, Zibusiso Ndlovu, Jaishankar Sharma, Homa Mansoor, Madhura Bharati, Aparna Iyer, Nilma Hirani, Ameeta Joshi, Mabel Morales, Mrinalini Das, Pranita Tipre, Narendra Sutar, Stobdan Kalon, Gabriella Ferlazzo, Kathleen England (2023) PHA, 13(2): 43-49. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10290261/ Clinical Utility of Target-based Next-generation Sequencing for Drug Resistant TB: a pilot from Mumbai, India. Homa Mansoor, Nilma Hirani, Vijay Chavan, Mrinalini Das, Jaishankar Sharma, Madhura Bharati, Aparna Iyer, Mabel Morales, Ameeta Joshi, Stobdan Kalon, Gabriella Ferlazzo, Petros Isaakidis, Zibusiso Ndlovu, Kathleen England (2023) IJTLD, 27(1): 4148. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9879084/ Adoption and uptake of the lateral flow urine LAM test in countries with high tuberculosis and HIV/AIDS burden: current landscape and barriers. Diane N. Singhro, Emily MacLean, Mikashmi Kohli, Erica Lessem, David Branigan, Kathleen England, Khairunisa Suleiman, Paul K. Drain, Morten Ruhwald, Samuel Schumacher, Claudia M. Denkinger, Brenda Waning, Wayne Van Gemert, Madhukar Pai (2020) Gates Open Res 13(4):24. https://gatesopenresearch.org/articles/4-24/v2 Detecting Tuberculosis: rapid tools but slow progress. Kathleen England, Tiziana Masini, and Emmanuel Fajardo (2019) PHA 9(3):80. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6827489/pdf/i2220-8372-9-3-80.pdf Key features to consider revising the EDL - a TB perspective. Suleiman, Khairunisa; England, Kathleen; Lessem, Erica; McKenna, Lindsay (2019) Int J Tuberc Lung Dis, 23(2): 272. The within-host population dynamics of Mycobacterium tuberculosis vary with treatment efficacy, Andrej Trauner; Qingyun Liu; Laura E Via; Xin Liu; Xianglin Ruan; Lili Liang; Huimin Shi; Ying Chen; Ziling Wang; Ruixia Liang; Wei Zhang; Wang Wei; Jingcai Gao; Gang Sun; Daniela Brites; Kathleen England; Guolong Zhang; Sebastien Gagneux; Clifton E Barry; Qian Gao (2017) BMC Genome Biology, 18:71. https://genomebiology.biomedcentral.com/articles/10.1186/s13059-017-1196-0 Interferon-Gamma Responses to Treatment in Active Pulmonary and Extrapulmonary Tuberculosis, Lili Liang, Ruiru Shi, Xin Liu, Xin Yuan, Shulan Zheng, Guolong Zhang, Wei Wang, Jing Wang, Kathleen England, Laura E. Via, Ying Cai, Lisa C. Goldfeder, Lori E. Dodd, Clifton E. Barry 3rd, Ray Y. Chen (2017) Int J Tuberc Lung Dis. Oct 1;21 (10):1145-1149. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310125/ Efficacious combination therapy minimizes positive selection of antibiotic resistance. Andrej Trauner, Qingyun Liu, Laura E. Via, Xin Liu, Xianglin Ruan, Lili Liang, Huimin Shi, Ying Chen, Ziling Wang, Ruixia Liang, Wei Zhang, Wang Wei, Jingcai Gao, Gang Sun, Kathleen England, Guolong Zhang, Sebastien Gagneux, Clifton E. Barry, III, Qian Gao. (2016) Proc Natl Acad Sci USA A sterilizing tuberculosis treatment regimen is associated with faster clearance of bacteria in cavitary lesions in marmosets. Laura Via, Kathleen England, Danielle Weiner, Daniel Schimel, Matthew Zimmerman, Emmanuel Dayao, Ray Chen, Lori Dodd, Mike Richardson, Katherine Robbins, Ying Cai, Dima Hammoud, Peter Herscovitch, Veronique Dartois, JoAnne Flynn, and Clifton Barry. (2015) Antimicrob Agents Chemother 59 (7):4181-9 (PMID:25941223). https://pubmed.ncbi.nlm.nih.gov/25941223/ Anti-vascular endothelial growth factor treatment normalizes tuberculosis granuloma vasculature and improves small molecule delivery. Meenal Datta , Laura E. Via , Walid S. Kamoun , Chong Liu , Wei Chen, Giorgio Seano , Danielle M Weiner , Daniel Schimel , Kathleen England , John D. Martin , Xing Gao , Lei Xu , Clifton E Barry, III , Rakesh K Jain. (2015) Proc Natl Acad Sci USA (PMID;25624495). https://pubmed.ncbi.nlm.nih.gov/25624495/ Meropenem-clavulanic acid shows activity against Mycobacterium tuberculosis in vivo. K. England, H. Boshoff, K. Arora, D. Wiener, E. Dayao, D. Schimel, L.Via and C. Barry. (2012) Antimicrob Agents Chemother (PMID:22450968). https://pubmed.ncbi.nlm.nih.gov/22450968/ Lessons Learned about Pneumomic Plague Diagnosis from 2 Outbreaks, Democratic Republic of the Congo. E. Bertherat, P.Thullier, J. C. Shako, K. England, K. Mamadou-Lamine, L. Arntzen, H. Tomaso, L. Koyange, P. Formenty, F. Ekwanzala, R. Crestani, L.Rahalison. (2011) Emer Infect Diseases. 17(5):778-84 (*special highlight as a CME article). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3321750/ DOCTORAL/GRADUATE WORK MadR1, a Mycobacterium tuberculosis a cell cycle stress respnse protein that is a member of widely conserved protein class of prokaryotic, eukaryotic and archaeal origin. Rebecca Crew, Melissa V Ramirez, Kathleen England and Richard A Slayden. (2015) Tuberculosis, 95(3):251-8. https://pubmed.ncbi.nlm.nih.gov/25829286/ MazF6 toxin of Mycobacterium tuberculosis demonstrates antitoxin specificity and is coupled to regulation of cell growth by a Soj-like protein. Melissa V. Ramirez, Clinton C. Dawson, Rebecca Crew, Kathleen England, and Richard A. Slayden. (2013) BMC Microbiology, 13:240. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834876/ Mycobacterium tuberculosis septum site determining protein, Ssd encoded by rv3660c, promotes filamentation and elicits an alternative metabolic and dormancy stress response. K. England, R. Crew, and R. Slayden. (2011) BMC Microbiology, 11:79. https://bmcmicrobiol.biomedcentral.com/articles/10.1186/1471-2180-11-79 Mechanistic Analysis of the FabI Enoyl-ACP Reductase from Burkholderia pseudomallei. Nina Liu, Jason E. Cummings, Kathleen England, Richard A. Slayden, and Peter J. Tonge. (2011) J Antimicrob Chemother. 66(3):564-73. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3037155/ Substituted diphenyl ethers as a broad-spectrum platform for the development of chemotherapeutics for the treatment of tularemia. K. England, C. amEnde, H. Lu, T. Sullivan, N. Marlenee, R. Bowen, S. Knudson, D. Knudson, P. Tonge and R. Slayden. (2009) J Antimicrob Chemother 64: 1052-1061. https://pubmed.ncbi.nlm.nih.gov/19734171/ Slow-Onset Inhibition of the FabI Enoyl Reductase from Francisella Tularensis: Residence Time and In Vivo Activity. H. Lu, K. England, C. amEnde, S. Luckner, N. Marlenee, R. Bowen, S.Knudsen, D. Knudsen, C. Kisker, R. Slayden and P. J. Tonge. (2009) ACS Chem Biol 4(3):221-31. https://pubs.acs.org/doi/10.1021/cb800306y Drug Discovery: Fransicella tularensis and Mycobacterium tuberculosis. Kathleen England Brostrom (2009) Doctoral Dissertation, Colorado State University. Waterstone Publishing: https://www.waterstones.com/book/drug-discovery-for-francisella-tularensis-and-mycobacterium-tuberculosis/kathleen-england-brostrom//9781243679543 Are Fecal Sterols A Possible Alternative Indicator Of Human Waste Contamination In Hawaiian Recreational Waters? Kathleen England Brostrom (2005) Master of Science Thesis, University of Hawaii. https://scholarspace.manoa.hawaii.edu/server/api/core/bitstreams/b907d6b5-971a-48db-82c8-e3a5c8a2bea2/content Application of Innovative Methods and Strategies to Differentiate Sewage from Non-Point Source Pollution in Hawaii. England and R. Fujioka (2005). WWRC Newsletter. https://www.wrrc.hawaii.edu/wp-content/uploads/sewage.pdf A metal ion-binding site in the kringle region of bovine prothrombin fragment 1. P.Berkowitz, H.Huh, K. Brostrom. (1992) J Biochem 267(7): 4570-4576. https://www.sciencedirect.com/science/article/pii/S0021925818428712

Areas of research

• Molecular Diagnostics, Tuberculosis, Infectious Biothreat Pathogens, Drug Discovery

Hobbies / Sports

• painting, cooking, hiking, snorkeling, traveling

Favorite professional publications

• Mountains beyond Mountains by Tracy Kidder

Areas of research

Infectious Disease Diagnosis, Tuberculosis, HIV, and NTDs, Drug Discovery

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