For Some Crohn's Patients, This Dysfunctional Gene Could Be the Cause

This discovery led the researchers to suggest that the cause of Crohn’s disease in these patients may not merely be related to oxidative stress, but to dysfunctional MDR1 as well. For these patients, bile acid sequestrants may prove to be an effective form of treatment for restoring normal T cell function in the ileum because these drugs absorb bile acids much like a sponge.