Dr. James Elliott Bradner MD
Hematologist-Oncologist | Hematology & Oncology
44 Binney St Dana-Farber Cancer I Boston MA, 02115About
Dr. Bradner received his MD from The University of Chicago in 1999. He completed his postgraduate training in Internal Medicine at Brigham and Women's Hospital, followed by a fellowship in Medical Onc ...
Education and Training
Univ of Chicago, Pritzker Sch of Med, Chicago Il 1999
Pritzker School Of Med University Of Chicago 1999
Board Certification
Internal MedicineAmerican Board of Internal MedicineABIM- Hematology
Internal MedicineAmerican Board of Internal MedicineABIM- 2002
Internal MedicineAmerican Board of Internal MedicineABIM- Medical Oncology- 2005
Provider Details
Expert Publications
Data provided by the National Library of Medicine- Differential transactivation by alternative EWS-FLI1 fusion proteins correlates with clinical heterogeneity in Ewing's sarcoma.
- Small-molecule inhibition of proteasome and aggresome function induces
- Intracellular protein degradation and its therapeutic implications.
- A robust small-molecule microarray platform for screening cell lysates.
- Lymphocyte chemotaxis is regulated by histone deacetylase 6, independently of its deacetylase activity.
- A method for the covalent capture and screening of diverse small molecules in a microarray format.
- Fluorous-based small-molecule microarrays for the discovery of histone deacetylase inhibitors.
- Structural origin of selectivity in class II-selective histone deacetylase inhibitors.
- HDAC6 inhibition enhances 17-AAG--mediated abrogation of hsp90 chaperone function in human leukemia cells.
- Total synthesis and biological mode of action of largazole: a potent class I histone deacetylase inhibitor.
- Synthesis and conformation-activity relationships of the peptide isosteres of FK228 and largazole.
- A pulse at the heart of targeted therapy.
- Synthesis and histone deacetylase inhibitory activity of largazole analogs: alteration of the zinc-binding domain and macrocyclic scaffold.
- Identification and characterization of small molecule inhibitors of a class I histone deacetylase from Plasmodium falciparum.
- Tubacin kills Epstein-Barr virus (EBV)-Burkitt lymphoma cells by inducing reactive oxygen species and EBV lymphoblastoid cells by inducing apoptosis.
Awards
- 2010-2011 Damon Runyon-Rachleff Innovation Award
- 2010 Smith Family Award for Excellence in Biomedical Research
- Dunkin Donuts 2007 Rising Star Award
- American Society of Hematology 2006 Fellow Scholar Award
- Brigham & Women's Hospital 2005 Distinguished Excellence in Teaching Award
- Harvard Medical School 2002 Golden Hammer Teaching Award
- 1995 Bok Teaching Award
- 2011 Smith Family Foundation Award for Biomedical Research Excellence
- 2013 Alpha Omega Alpha Beta Chapter, Univ. of Chicago Alumni Honoree
- 2007-2008 Dunkin Donuts Rising Star Award
Treatments
- Multiple Myeloma, Stem Cell Transplant
Fellowships
- Dana-Farber/Partners CancerCare, Hematology/Oncology 2002
- Dana Farber Cancer Institute, Fellow 2002
- Dana Farber Cancer Institute, Fellow:Hematology/Oncology 2002
- Broad Institute of Harvard and MIT, Fellow:Chemical Pathology 2004
Dr. James Elliott Bradner MD's Practice location
Practice At 44 Binney St Dana-Farber Cancer Institute
44 Binney St Dana-Farber Cancer I -Boston, MA 02115Get Direction
Dr. James Elliott Bradner MD's reviews
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What are the Stages of Multiple Myeloma?This is the uncommon type of cancer that forms in plasma cells. A type of white blood cells found in the body, plasma cells, identify and battle germs and infections that attack the body.In multiple myeloma patients, the healthy plasma cells are overtaken by cancer cells. This reduces the number of...
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Lymphoma News: Mother Gives Birth to Healthy Daughter after Chemo During PregnancyChemotherapy has a reputation for its not-so-great side effects. As many people know, chemotherapy is known to cause off target symptoms for most cancer patients such as nausea and vomiting, hair loss, and extreme fatigue. In addition to the symptoms that one may experience during treatment, some of...
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Nearest Hospitals
BRIGHAM AND WOMEN'S HOSPITALl
75 FRANCIS STREET BOSTON MA 2115BOSTON CHILDREN'S HOSPITALl
300 LONGWOOD AVENUE BOSTON MA 2115